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KMID : 0613820120220060730
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Journal of Life Science
2012 Volume.22 No. 6 p.730 ~ p.735
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Study on Cosmeceutical Activities and Anti-inflammatory Activities of Magnolia biondii Extracts
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Kim Young-Hun
Sung Ji-Yeon
Seo Kyo-Seong
Shin Jae-Cheon
Kim Byung-So
Yeum Jeong-Hyun
Lee Jin-Tae
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Abstract
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Existing pharmaceutical studies show that Magnolia biondii is effective in treating rhinitis and in reducing cholesterol, given its endogenous, volatile ingredients. The study herein seeks to assess the cosmeceutical activities and anti-inflammatory activities of Magnolia biondii extracts for possible application as cosmetic ingredients. The cosmeceutical and anti-inflammatory activities were investigated using hydroxyl radical scavenging, superoxide dismutase (SOD)-like activity, xanthine oxidase (XO) inhibition, cell viability, nitric oxide (NO) inhibition, and inducible nitric oxide synthase (iNOS) expression by Western blotting. Magnolia biondii extracts were identified to have antioxidant activities in hydroxyl free radical scavenging, SOD-like activity, and XO inhibition. In testing the anti-inflammatory activities of the extracts, NO production was inhibited in a dose-dependent manner. Additionally, in a dose-dependent manner, the Magnolia biondii extracts were able to suppress iNOS expression in LPS-stimulated RAW 264.7 macrophage cells. From these results, Magnolia biondii showed adequate potential for application in cosmetic production and related industries as well as a functional material.
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KEYWORD
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Anti-inflammatory, cosmeceutical, induced nitric oxide synthase, Magnolia biondii, nitric oxide
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